49ers vs Panthers Betting Preview Brings Excitement


Posted: October 6, 2022

Updated: October 6, 2022

  • Garoppolo vs Mayfield - Who would you rather have as QB?
  • Expect low numbers on Sunday
  • Betting preview for Week 5 - 49ers vs Panthers

San Francisco isn’t doing that great this season so far, but Carolina is in a much worse position. The Panthers are ranked last in offense and 30th in passing. Comparatively, the 49ers aren’t that much better but at least they got the rushing covered. They’re ranked 9th in the league overall. Plus, they beat the reigning champions Rams 24-9 last week. The 49ers vs Panthers betting previews all favor the visitors. San Francisco is favored by anywhere between 4.5 and 6.5 points.

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We’re expecting to see a physical, low-scoring game on Sunday. Furthermore, covering a 6.5-point spread will be a bit tough, so don’t go with the 49ers on this one. As for the moneyline, San Francisco should be able to force a win in Carolina. But expect the total to be less than 38.5 points in the end. Garoppolo and Mayfield, what a strange matchup. Where do you see them next season?

The best betting odds for the 49ers vs Panthers

Teams Spread Moneyline Total
San Francisco 49ers

-6.5 (-113)

A $100 bet would return $188.50


Over 38.5 points (-113)

Under 38.5 points (-107)

Bet on Bet Online
Carolina Panthers +6.5 (-107)


A $100 bet would return $330