The Best 2022 Champions League Round of 16 Betting Tips


Posted: March 2, 2022

Updated: January 26, 2024

  • Tears of joy and sadness will be shed in the 2nd leg
  • The battle of the giants - Real or PSG
  • Can Ronaldo step into the spotlight on 15 March?
  • The best betting tips for the 2022 Champions League Round of 16
  • The English teams are dominating the competition

The Champions League is about to return and no doubt it will make some fans cry. This beautiful game we call football unites millions every year with the highest competition in the world. In this article, we’ll be focusing on the 2nd leg of Round 16. Here we will list the predictions for the upcoming matches, including odds for wins, draws, and losses. You will also find some really useful betting tips for the 2022 Champions League Round of 16. Which bets to avoid, injury reports, home team advantages, and more.

bet365 Sportsbook Welcome Bonus

Bet £10 & Get £30 in Free Bets

Bet £10 & Get £30 in Free Bets for new customers at bet365. Min deposit requirement. Free Bets are paid as Bet Credits and are available for use upon settlement of bets to value of qualifying deposit. Min odds, bet and payment method exclusions apply. Returns exclude Bet Credits stake. Time limits and T&Cs apply

In a previous article, we covered the 1st leg of Round 16 which involved a couple of surprises. As the competition gets smaller, so will the betting options. After all, more teams and matches mean more opportunities. So without further ado, we give you the best 2022 Champions League Round of 16 betting tips and predictions you can find online.

Quick Summary Of Results and Previous Predictions

With the 1st leg of the UEFA Champions League Round of 16 done we’re getting ever closer to that sweet final. The February matches have produced some mixed results. They more or less went the same way the experts predicted, however. PSG was predicted to win against Real, and they did it in a 1-0 game in Paris. Manchester City also didn’t disappoint as they beat Sporting 5-0. As the heavy favorites, this was no surprise either. Liverpool also won against Inter in a 2-0 game in Milan. The biggest surprise and perhaps the most entertaining match was Bayern-Salzburg. Bayern had over 75% chance of winning the match but the Austrians pulled out a draw. The Bavarians’ hides were only saved by a 90th-minute equalizer by Coman. 

Reigning UCL champions Chelsea beat LOSC Lille 2-0 as predicted. The remaining three games from the 1st leg of Round 16 were nerve-racking. They all ended in draws. Neither Villarreal nor Juventus could gain the upper hand in Spain as the game ended 1-1. Online sportsbooks in the UK predicted that a draw would be the most unlikely result. Atlético and Man United most likely sent fans into a frenzy as the game felt like an eternity until United levelled the score in the 80th minute. Both sides just kept missing the goal. Finally, the Benfica-Ajax game was also a sight to see. As experts heavily favoured Ajax to win, they could only settle for a 2-2 draw in the Portuguese capital. If you’re interested check out our UCL Round of 16 1st leg predictions and how they turned out.

Away Goals Rule Tip For The 2022 Champions League Round of 16

As you have seen from the 1st leg results, the experts’ predictions are not always accurate. They are still the best predictions and odds you can find but football is not a fixed sport. It’s easy to understand odds and numbers but we’re going to try to list some additional tips here for you. It’s nice to consider these before betting on any of the teams in the 2nd leg of this competition we all love. First and foremost, remember the away goal rule that produced some of the best matches in Champions League history? Yeah, it’s gone. Maybe this means no more bus parking in crucial games but it’s still an important piece of football history. Instead, tie games will go to extra time, which will be 15 minutes per half. A level result will bring on a penalty shootout. Let’s see some predictions now.

Insane Odds For the First Matchday of the 2nd leg

Salzburg went and proved its doubters wrong in the 1st leg but can they do it again? Since there’s no aways goal rule, there is one question on our mind for their upcoming match. Will they go on the offensive or try to settle for a draw and go to penalties?

Look away Salzburg fans because Bet365 Sportsbook’s odds are nowhere near in favour of the Austrians. Bayern has 1.18 odds of winning in Münich while Salzburg is far behind with 12.00 odds. For example, if you were to bet £100 on Salzburg and they win, you would receive £1.200. Their chances are low but not impossible. The odds for another draw are 8.00, which is still low. The last time Bayern lost a UCL home game was almost a year ago when PSG beat them 3-2 in the Allianz.

Liverpool has been a force to be reckoned with in the past few years. The Reds have won both the Premier League and the Champions League in the past couple of years. They also have Mo Salah, the favorite for the PFA Player of the Year this season. Their odds of winning the 2nd leg are 1.53 compared to Inter’s 5.50. A draw is also not out of the question with 4.33 odds. The English teams are simply on another level this season. Liverpool is the only undefeated team so far in this year’s Champions League. The two teams’ fate will be determined on 8 March. While experts don’t think the game will go to extra-time, let alone to the penalties, this is football. Do you think Inter can produce a win at Anfield? With Liverpool’s run this year, we find it unlikely.

Important Injury Report For the 2022 Champions League Round of 16

Key Bayern players Manuel Neuer and Alphonso Davies are still out with injuries. Davies’ heart condition is concerning as he’s one of the most promising left-backs in the world. He has missed 7 games since he was declared unavailable.

Neuer is out with knee surgery since 6 February and most likely won’t return for their 2nd leg match. Injuries like his could take months to recover from. If Salzburg goes on the offensive secondary keeper Sven Ulreich will have to step up his game. This is just a small tip if you’re considering betting on away goals. Bayern is still the favourite but Salzburg can still bag some much-needed goals. Salzburg’s Andreas Ulmer is risking suspension with 4 yellow cards and starting forward Noah Okafor has joined the already long list of injured players since the 1st leg.

Liverpool fans are aware of Thiago’s injury issues. The midfielder was injured minutes before the League Cup final with Chelsea. Online sportsbook news in the UK reported that due to the Reds’ win his absence was overlooked. According to Jurgen Klopp, his injury is not that serious and he should be ready for the Inter game on 8 March. Another issue is Roberto Firminho. The forward scored the first goal of the game after coming off the bench in the second half. His return to the squad is still unclear. Inter’s starting forward Martínez will have to be careful as he’s risking suspension with his 4 yellow cards. On the other hand, midfielder Nicoló Barella’s red card suspension ends on 9 March, a day after their 2022 Champions League Round of 16 2nd leg game. Barella, a key player in the starting eleven will also miss their 2nd Liverpool match.

2022 Champions League Round of 16 – Who will advance on 9 March?

There’s no need to prolong the inevitable here. After City beat Sporting 5-0 in Lisbon, the Portuguese side will need a miracle in the 2nd leg. Even if the away goals rule were present this year, it would still favour Man City. Any game where a home loses 0-5 is nothing short of a massacre. This Round of 16 match has the highest odds deficit too. Bet365 Sportsbook favours City with 1.14 odds, while Sporting’s hopes are dying with 15.00 odds of winning.

bet365 Sportsbook Welcome Bonus

Bet £10 & Get £30 in Free Bets

Bet £10 & Get £30 in Free Bets for new customers at bet365. Min deposit requirement. Free Bets are paid as Bet Credits and are available for use upon settlement of bets to value of qualifying deposit. Min odds, bet and payment method exclusions apply. Returns exclude Bet Credits stake. Time limits and T&Cs apply

The odds for a draw are 8.00 but City would still advance that way. Man City is still the favourite to win the Premier League and they also became the favourite for the UCL title with 3.25 odds. There might be someone that can stop them this year, but it won’t be Sporting. Sorry Sporting fans, life is unfair sometimes.

The second match of 9 March will no doubt draw in some incredible viewership numbers. Real will host PSG in the Bernabéu as they are down 0-1 in aggregate. The odds, just like for the 1st leg match, are quite even. Experts give Los Blancos 2.45 odds of winning the game, while the Parisians are not far behind with 2.60. The odds for a draw is 3.75. As both clubs have a huge fan following, this match from the 2022 Champions League Round of 16 might turn out to be the most nerve-racking. While PSG’s chances for qualification are higher right now, a 1 goal deficit is not that big of a deal for Real. The Spanish club has some legendary UCL comebacks to their name, many of them in the past 10 years. The question is, can they do it again next week?

Bet Smarter On One-Sided or Even Games

The Man City and Sporting match has some great odds and betting options. Instead of trying to bet on City, who has 1.14 odds of winning, try something else. Only if you’re feeling lucky, however. Betting on the outcome of the games is the most common way of this trade, but the chances are one-sided this time. 

Online sportsbook sites in the UK have many other options that are less risky but can still turn out profitable, nonetheless. For example, half-time/full-time bets are a safer way of risking your luck. A draw/Man City bet has odds of 3.75 which is not that great but it isn’t bad either. Penalties and winning from behind bets can also turn out as great options. Should Sporting take the lead, City has 7.00 odds of winning from behind. Explore more of these options instead.

Things are similar in the Real-PSG scenario. The winner’s odds are not that bad but the fact that they’re almost even is a sign that the outcome is uncertain. Since there’s only a 1 goal deficit in aggregate, anything can happen at this game. In the method of qualification category, for example, Real has 5.00 odds of doing it after 90 mins. This is small compared to PSG’s 1.53 but it’s a much better option than the plain outcome of the game. Just a reminder that Real is also missing Casemiro, an important piece of their starting eleven. Real leading both halves also has odds of 4.00 and is a scenario that’s not unlikely to happen. Try to explore goal-scoring bets too. Benzema is just 2 goals away from tying Raúl for the second-highest goalscorer in Real Madrid UCL history.

Here’s Hoping For No More Draws With These Four

During the second week of the 2nd leg, Ajax will face Benfica in Amsterdam. When it comes to head-to-head history, Ajax has the winning record. But keep in mind that experts predicted Benfica will lose the 1st leg match too but they managed to put on an entertaining performance that concluded in a 2-2 draw in Lisbon. There’s the saying that lightning doesn’t strike the same place twice and it certainly looks like that from the available odds. The odds of Ajax winning are 1.44 while Benfica’s are 7.00. That’s a huge difference.

bet365 Sportsbook Welcome Bonus

Bet £10 & Get £30 in Free Bets

Bet £10 & Get £30 in Free Bets for new customers at bet365. Min deposit requirement. Free Bets are paid as Bet Credits and are available for use upon settlement of bets to value of qualifying deposit. Min odds, bet and payment method exclusions apply. Returns exclude Bet Credits stake. Time limits and T&Cs apply

The chances of another draw are 4.75. Now, remember that Ajax emerged 6-0, unbeaten from their group while Benfica finished with 8 points in second. One could argue that Group E might’ve been harder but it’s too late for that now. Numbers are not always correct but they provide an idea of the outcome.

The 2022 Champions League Round of 16 1st leg match between Man United and Atlético left many fans furious. If you’ve watched the game, you know why. On 15 March the Spanish side will head to the Theatre of Dreams with the plans of giving United fans another nightmare. This time, however, it is the Manchester side that is the favourite for winning. Bet365 Sportsbook has United winning 2.05 odds, while Atlético’s chances are 3.80. Another draw could happen at the odds of 3.20. The home teams always have the advantage. But what if things go differently, and we see the Red Devils lose? After all, what is the UCL without Ronaldo? Tell us in the comments what you think is going to happen. One club will advance, but how far do you think they will go in the competition?

Home Team Advantages and What It Means For The Visitors

Ajax has won all of their group stage games and this is why Benfica should be worried. The Amsterdam team has won their Champions League home games this season by a 2 goal advantage or higher. This is also one of the reasons why their odds of winning in the 2nd leg are higher.

To give credit to Benfica, they won all of their qualifying and playoff home games. In the group stage, they’ve only lost to Bayern in a 0-4 match. Let’s be fair, there’s no shame in losing to Bayern. Right, Barca fans? Yes, Benfica’s chances for advancing are much lower than those of Ajax but there’s still hope. You shouldn’t count out the Portuguese although it will be a tough match. The Ajax-Benfica matchup is one of the better ones in the 2022 Champions League Round of 16.

Manchester United has gone through quite a bit of change in the past year. Summer and January transfers, loans, coach changes, rumours about locker room issues, and so on. United haven’t lost any of their UCL home games this season. The concern is they either drew or only one by one goal. The good thing is that winning by one goal this time is enough for them to advance to the quarter-finals. On the other hand, Atlético seems to perform better on the road this season. Well, when it comes to the Champions League at least. They won 2 of their 3 away games in the group stage while also not winning a single home game. Online sportsbook news in the UK also reports that United has the advantage in the 2nd leg. Not too long until we find out.

bet365 Sportsbook Welcome Bonus

Bet £10 & Get £30 in Free Bets

Bet £10 & Get £30 in Free Bets for new customers at bet365. Min deposit requirement. Free Bets are paid as Bet Credits and are available for use upon settlement of bets to value of qualifying deposit. Min odds, bet and payment method exclusions apply. Returns exclude Bet Credits stake. Time limits and T&Cs apply

The Last Day Of The 2022 Champions League Round of 16

Juventus will host Villarreal in Torino on the final day of Round 16. While Juventus was favoured to win the 1st leg match, the game ended in a draw. This time around, the Italians are the favourites once again. They have 1.83 odds of winning compared to Villarreal’s 4.20. The chance for a draw is 3.60 this time. This is also lower, compared to the 3.06 odds in the previous game. Chances of qualifying are not so different, however. Juventus has an impressive 1.40 chance while Villarreal’s 2.75 isn’t that bad either. The Spaniards’ recent performance has been steadily improving. They’ve won 4 of their last 5 league matches, compared to Juventus’ 2. It’s just a matter of question if they can bring that energy into the 2nd leg as well.

Reigning UCL champions Chelsea is in a good position but they’re not out of the woods yet. They head to France with a 2-0 lead against Lille. Just like in the first match, Chelsea is the favorites again. According to Bet365 Sportsbook, their odds of winning are 1.72 compared to Lille’s 4.75. The French side put on a good performance in the 1st leg but they just couldn’t find the back of the net. But they’d have to win 2-0 at least to even advance to the penalties. Chelsea is currently the 5th favorites to win the UCL with 9.00 odds. One thing is certain, however. The last day of the 2022 Champions League Round of 16 will provide us with those much-anticipated fixtures for the quarter-finals.

Click here to stay tuned with bet365 Sportsbook

Notify of
Inline Feedbacks
View all comments